Synthesis of bis chromene derivative as a dual-functional corrosion inhibitor and CDK2 targeting agent

• S.A. Saoud¹, S.A. Habeeb¹, M.I. Ali² and H.A. Almashhadani²

¹ Department of Chemistry, College of Education for pure science (Ibn Al-Haitham), University of Baghdad, Baghdad 61023, Iraq
² Department of chemistry, College of Science, University of Baghdad, Baghdad, Iraq

Abstract: (Nˊ1Z,Nˊ6Z)-Nˊ1,Nˊ6-Bis(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-ylidene)adipohydrazide was synthesized and characterized using nuclear magnetic resonance (¹H-NMR, ¹³C-NMR) and Fourier Transform Infrared spectroscopy (FTIR). The synthesis of chromene derivatives has garnered significant interest due to their wide range of biological activities and applications in medicinal chemistry, particularly pharmaceuticals. The current study highlights recent advancements in chromene derivatives and their role in the corrosion inhibition of carbon steel (CS), which was studied using electrochemical polarization techniques and electrochemical impedance spectroscopy (EIS) in a saline solution (3.5% NaCl) and an inhibited saline solution containing 200 ppm of the inhibitor over a temperature range of 303–323 K. The highest inhibition efficiency (IE%) of the synthesized inhibitor was 95.26% at 303 K. An atomic force microscope (AFM) was used to examine the surface morphology of the CS in both free and inhibited solutions. Kinetic and thermodynamic parameters of the transition state, including the apparent activation energy (E_a*), pre-exponential factor (A), activation enthalpy (∆H*), activation entropy (∆S*), and Gibbs free energy of activation (∆G*), were estimated. Additionally, a significant portion of the study explores molecular docking with CDK2 and includes comparisons to anticancer drugs. The prepared compound showed potential as a drug for breast cancer, although further studies are required to validate its efficacy.

Keywords: quercetin, adipohydrazide, chromene, corrosion inhibitor, carbon steel, molecular docking

Int. J. Corros. Scale Inhib., 2025, 14, no. 2, 905-929
doi: 10.17675/2305-6894-2025-14-2-25

Download PDF

Back to this issue content: 2025, Vol. 14, Issue 2 (pp. 420-... (in progress))