ISSN 2305-6894

Recycling and application of expired desloratadine medicinal drugs for inhibition of steel corrosion in acid environment: Analytical studies

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1 Basic Science Department, Preparatory Year, University of Ha’il, 1560, Hail, KSA
2 Chemistry Department, Faculty of Science, Al-Azhar University,11884, Cairo, Egypt
3 Chemistry Department, Faculty of Science, Umm Al-Qura University, Makkah Mukaramha, KSA
4 Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, KSA
5 Department of Pharmaceutics, Faculty of Pharmacy, University of Ha’il, 1560, Hail, KSA
6 Chemistry Department, College of Science, University of Jeddah, Jeddah 22233, Saudi Arabia

Abstract: Desloratadine medicinal drug tablets known as Clarinex is a complex formulation comprising desloratadine, excipients, and a coating. It is a famous antihistamine used only for adult patients. It is dangerous to be left in the environment after its expiration as it is harmful to children. So, the present work introduces the idea of using Desloratadine tablets in expired form as green corrosion inhibitors for steel in 1.0 N HCl. Five analytical techniques were used to evaluate the inhibition performance of expired Desloratadine drug, namely gravimetric, atomic absorption spectroscopy (AAS), thermometric, gasometric, and acidimetric techniques. The effect of expired drug concentration, reaction temperature, and pH was studied. Corrosion inhibition was found to increase with an increase in concentration and to decrease with rising temperature and a decrease in pH. The techniques used are in good agreement with each other (±2%) indicating that it is possible to use the expired Desloratadine drug as a potential nontoxic green corrosion inhibitor for steel in industrial field at low pH values.

Keywords: expired drugs, green inhibitors, gravimetric, thermometric, AAS, acidimetric

Int. J. Corros. Scale Inhib., , 10, no. 4, 1748-1765
doi: 10.17675/2305-6894-2021-10-4-24

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